idebenone, a stimulator of NGF synthesis, recovers reduced NGF content in aged rat brain

Oral administration of idebenone, a stimulator of NGF synthesis, recovers reduced NGF content in aged rat brain.

Nitta A, Hasegawa T, Nabeshima T.

Department of Neuropsychopharmacology and Hospital Pharmacy,
Nagoya University School of Medicine, Japan.
Neurosci Lett 1993 Dec 12;163(2):219-22

ABSTRACT

The relationship between nerve growth factor (NGF) and senile dementia of the Alzheimer type is of interest. We demonstrate here that the oral administration of idebenone, a stimulator of NGF synthesis in vitro, produced recovery of reduced NGF content in aged rat brain. Twenty-one-day successive administration of idebenone produced significant recovery of reduced NGF content in the frontal cortex and parietal cortex of aged rats. These results suggest that NGF content in the brain is low in aged rats and that oral administration of idebenone leads to a recovery of this reduction.

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Idebenone - the ultimate anti-aging drug. (article)

Alzheimer's disease
Idebenone  in the treatment of Alzheimer's disease
Idebenone efficacy of idebenone in the treatment of Alzheimer's disease
Idebenone Nerve Growth Factor synthesis stimulators in Alzheimer's disease
Idebenone in the treatment of dementia of the Alzheimer type
Idebenone cognitive enhancement therapy for Alzheimer's disease

Friedreich's ataxia.
Idebenone and reduced cardiac hypertrophy in Friedreich's ataxia.
Idebenone causes improvement in mitochondrial cardiomyopathy
Idebenone cerebellar improvement in Friedreich's ataxia after 3 months
Idebenone   effect of idebenone on cardiomyopathy in Friedreich's ataxia
Idebenone Friedreich's ataxia and frataxin
Idebenone   Frataxin: Its role in iron metabolism and Friedreich's Ataxia
Idebenone   mitochondrial dysfunction in Friedreich's ataxia
Idebenone   helps heart function in Friedreich's ataxia

MELAS
Idebenone improves cerebral mitochondrial oxidative metabolism in MELAS
Idebenone in young patients with mitochondrial encephalomyopathy (MELAS)
Idebenone therapy in Mitochondrial encephalomyopathy (MELAS)
Idebenone and Mitochondrial encephalomyopathy (MELAS)
Idebenone successful therapy with idebenone in Mitochondrial encephalomyopathy (MELAS)
.
Cardiomyopathy
Idebenone improvement in mitochondrial cardiomyopathy following treatment with idebenone
Idebenone   effect of idebenone on cardiomyopathy in Friedreich's ataxia
.
Leber hereditary optic neuropathy (LHON)
Idebenone does it shorten the time to visual recovery in Leber hereditary optic neuropathy?
Idebenone improvement in a patient with Leber's hereditary optic neuropathy (LHON)

Misc.
Idebenone use in age-related cognitive disorders

Idebenone protects hippocampal neurons against beta amyloid neurotoxicity

Idebenone functions as a potent protective hepatocyte antioxidant

Idebenone neuroprotective effects of idebenone can be attributed to its antioxidant ability

Idebenone inhibition of brain mitochondrial swelling

Idebenone suppression of cold ischemia/reperfusion injury of liver endothelium

Idebenone ability to eliminate a nitroxide radical in the rat

Idebenone interaction with respiratory complexes of heart mitochondria

Idebenone effect on serotonin release and seroton receptors in rats

Idebenone protects hepatic microsomes against damage in organ preservation solutions

Idebenone protects against toxicity induced by low density lipoprotein

Idebenone protects against disorders due to cerebral hypoxia or ischemia

Idebenone protects against toxicity induced by low density lipoprotein

Idebenone attenuates neuronal degeneration induced by excitotoxins

Idebenone augments long-term potentiation in hippocampal slices in the guinea pig

Idebenone effects on electroencephalograms of patients with cerebrovascular disorders

Idebenone effects on respiratory activities of brain mitochondria

Idebenone effects on lipid peroxidation in erythrocytes of stroke-prone, hypertensive rats

Idebenone brain distribution and its effect on local cerebral glucose utilization in rats

Idebenone effects on acetylcholine levels in the brains of rats with cerebral ischemia

Idebenone protective effect of idebenone against hypoxia in mice

Idebenone improves learning and memory impairment induced in rats

Idebenone effects of idebenone on neurological deficits in stroke-prone rats

Idebenone effects on memory induced impairment in rats

Idebenone effects of idebenone on cerebral blood flow in rats with cerebral ischemia

Idebenone inhibition of brain mitochondrial swelling by idebenone

Idebenone inhibition of platelet aggregation by idebenone

Idebenone effects of idebenone on monoamine metabolites of patients with dementia

Idebenone effects of idebenone on metabolism of monoamines and cyclic AMP formation

Idebenone effects on impairment of radial maze learning in cerebral embolized rats

Idebenone effect of idebenone on lipid peroxidation in rat brain homogenate

Idebenone effects on muricidal behavior in rats with raphe lesions

Idebenone inhibitory effect of idebenone on vascular lesions in hypertensive rats

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