Suppression of leukocyte-enhanced cold
ischemia/reperfusion injury of liver endothelium with the benzoquinone
Schutz E, Wieland E, Hensel A, Niedmann PD,
Dreiss A, Armstrong VW, Schuff-Werner P, Oellerich M.
Abteilung Klinische Chemie,
Georg-August-Universitat, Gottingen, Germany.
Clin Biochem 1997 Dec;30(8):619-24
The effects of idebenone
neurological deficits following cerebrovascular lesions were examined in
stroke-prone spontaneously hypertensive rats (SHRSP). The SHRSP were
maintained on a 1% NaCl solution as drinking water to shorten the onset time
of cerebrovascular lesions (stroke). After the onset of stroke, the salt
solution was exchanged for tap water, and idebenone
(30 and 100 mg/kg) was
administered orally once daily for 3 weeks. The neurological deficits were
evaluated by a specially designed scoring system or by an open-field test.
Idebenone decreased the severity of the neurological deficits in a
dose-dependent manner and this was statistically significant in the high-dose
group. The severity of neurological changes was inversely related to the motor
activity in the open-field test performed when the experiment was terminated,
indicating the appropriateness of the scoring system. Moreover, the compound
(100 mg/kg) significantly ameliorated a decrease in food intake (anorexia)
that followed the onset of stroke. These results suggest that idebenone may be
useful to treat patients with cerebrovascular lesions.